Symbol
Name
ID

Fgfr2
fibroblast growth factor receptor 2
MGI:95523

Phenotype annotations related to digestive/alimentary system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Esophageal atresia	Pyloric stenosis	Stomach cancer	Gastroesophageal reflux	Hepatocellular carcinoma
Disease(s) Associated with FGFR2	Esophageal atresia	Pyloric stenosis	Stomach cancer	Gastroesophageal reflux	Hepatocellular carcinoma
acrocephalosyndactylia
craniosynostosis
hepatocellular carcinoma
stomach cancer

Mouse Phenotypes

abnormal palatine bone horizontal plate morphology

abnormal palate development

abnormal palatal mesenchymal cell proliferation

abnormal secondary palate development

abnormal palatal shelf fusion at midline

palatal shelves fail to meet at midline

palatal shelf fusion with tongue or mandible

abnormal palate morphology

decreased palatal length

absent palatal rugae

cleft secondary palate

cleft palate

abnormal tongue morphology

tongue ankylosis

digestive/alimentary phenotype

abnormal digestive system morphology

abnormal cecum development

cecal atresia

abnormal rectum morphology

absent rectum

abnormal perineum morphology

abnormal salivary gland morphology

abnormal submandibular duct morphology

absent submandibular gland

submandibular gland hypoplasia

abnormal stomach morphology

abnormal stomach glandular region morphology

small stomach

abnormal intestinal glucose absorption

aerophagia

meteorism

Availability

Mouse Genotype

Fgfr2^m1Sgg/Fgfr2^m1Sgg

Fgfr2^tm1.1Dsn/Fgfr2^tm1.1Dsn

Fgfr2^tm1Schl/Fgfr2^tm1Schl

Fgfr2^tm2.1Lni/Fgfr2^tm2.1Lni

Fgfr2^tm2Schl/Fgfr2^tm2Schl

Fgfr2^tm3Dsn/Fgfr2^tm3Dsn

Fgfr2^tm4Lni/Fgfr2^tm4Lni

Fgfr2^m1Sgg/Fgfr2⁺

Fgfr2^tm1.1Dsn/Fgfr2⁺

Fgfr2^tm2.3Dsn/Fgfr2⁺

Fgfr2^tm1Ewj/Fgfr2⁺
Tg(EIIa-cre)C5379Lmgd/0 (conditional)

Fgfr2^tm2Dsn/Fgfr2⁺
Tg(Pgk1-cre)1Lni/0 (conditional)

Fgfr2^tm2Ewj/Fgfr2⁺
Tg(EIIa-cre)C5379Lmgd/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23